I still cannot find any sales data for Command & Conquer 4, Assassin's Creed II or the other games from the new DDRM crop. The only thing I have found that might be remotely indicative is a chart of players on Steam:
View Steam players per game
Top 75 games by current player count
Current Players Peak Today Game
53,238 96,304 Call of Duty: Modern Warfare 2 - Multiplayer
53,172 91,866 Counter-Strike: Source
43,428 76,097 Counter-Strike
17,568 23,976 Team Fortress 2
16,748 23,401 Football Manager 2010
16,059 21,979 Battlefield: Bad Company 2
11,604 17,565 Left 4 Dead 2
6,491 10,692 Empire: Total War
5,600 9,937 Napoleon: Total War
5,546 7,618 Garry's Mod
5,241 9,080 Condition Zero
4,595 10,551 Call of Duty: Modern Warfare 2
4,272 6,239 Torchlight
4,255 6,463 Warhammer 40,000: Dawn of War II - Chaos Rising
3,598 5,261 Left 4 Dead
3,491 6,166 Day of Defeat: Source
3,457 5,059 Football Manager 2009
3,252 5,130 R.U.S.E. Beta
2,696 4,330 Warhammer 40,000: Dawn of War II
2,460 3,737 Dragon Age: Origins
2,227 3,441 Just Cause 2
2,138 3,535 Supreme Commander 2
1,373 2,509 Half-Life 2: Deathmatch
1,371 1,942 Killing Floor
1,258 2,077 Half-Life 2
1,151 3,437 Metro 2033
1,089 1,618 Day of Defeat
927 1,342 Mass Effect 2
893 1,217 Grand Theft Auto IV
881 2,010 Aliens vs Predator
858 1,380 Borderlands
801 1,047 Global Agenda Live
759 1,165 Star Trek Online
712 731 Mount&Blade: Warband
688 935 Plants vs. Zombies
658 924 America's Army 3
637 899 Portal
548 864 Assassin's Creed II
538 898 The Settlers 7: Paths to a Kingdom
524 813 Mass Effect
505 723 Sid Meier's Civilization IV: Beyond the Sword
498 715 Mount and Blade
488 645 Company of Heroes: Tales of Valor
449 771 TrackMania Nations Forever
440 628 Zombie Panic! Source
416 645 Half-Life 2: Episode Two
389 887 RACE 07
381 499 EVE Online
376 897 Red Orchestra: Ostfront 41-45
371 552 Rome: Total War - Gold Edition
359 557 Company of Heroes
350 451 Titan Quest: Immortal Throne
334 607 Saints Row 2
327 499 Insurgency: Modern Infantry Combat
311 509 Half-Life 2: Episode One
300 434 Half-Life
299 410 S.T.A.L.K.E.R.: Call of Pripyat
287 385 Company of Heroes: Opposing Fronts
276 443 The Elder Scrolls IV: Oblivion - Game of the Year Edition
272 374 Global Agenda - Demo
271 378 Medieval II: Total War
261 433 Pirates, Vikings, and Knights II
243 306 Team Fortress classic
232 323 Audiosurf
225 338 League of Legends
224 351 Sid Meier's Civilization IV
221 416 Batman: Arkham Asylum
220 352 DiRT 2
219 295 Call of Duty 4: Modern Warfare
219 285 Battlefield 2
214 361 Command and Conquer 4: Tiberium Twilight
213 308 Defense Grid: The Awakening
208 268 EVE Online Demo
207 367 RailWorks
200 414 F.E.A.R. 2: Project Origin
The table is from about 6pm EST 29 March 2010. The bolding in the table is mine - I bolded both Ubisoft games with this DDRM - Assassin's Creed II and Settler's 7. Another Ubisoft game with the DDRM is Silent Hunter 5, but it does not appear in the top 75 games played today. I have also bolded Command and Conquer 4, which is a DDRM game by EA also requiring an always online connection.
I would say the numbers are rather unspectacular, given that Assassin's Creed 2 was released about 3 weeks ago, Settler's 7 was released 6 days ago in North America and 3 days ago in Europe. Silent Hunter 5, I believe, was released about 1 month ago. EA's Command & Conquer 4 was released on 16 March 2010, so just under two weeks ago.
However, this is only an indication that sales might not be stellar for a game release of that magnitude - it does not act as a confirmation by any stretch. For that we will have to wait for some sales numbers and those can be hard to come by (and can be interpreted in different ways).
Remember that C&C is a popular EA franchise and previous versions of the game have sold millions of copies. Yet, Dragon Age: Origins has more than 10 times the player numbers on Steam than C&C 4, despite the fact that it is a significantly older game and despite the fact that it probably didn't sell as many copies as previous versions of C&C. Sure, Steam players at one time are not the same as sales, but it might be an indirect indication of what is happening here.
Of course, EA has achieved the perfect storm with C&C 4 if it wished to kill the C&C franchise - it butchered the gameplay AND implemented a horrid DDRM system. Hopefully, they will not push Bioware to do the same. I am optimistic, but we need to watch out.