I've found quite a few examples where the 'renegade' option seems better than the paragon alternative.
Defending Tali - if you go all renegade, in your responses to the Admiralty board, both the admirals and the Conclave members make comments about your speaking well in Tali's defence, and about being wrong in thinking a human would be too weak to do a good job at defending Tali.
Conrad Verner - renegade the merchant (undercover cop) and Lie to Conrad, telling him it was a dangerous mission, he did a good job, but could have been killed, and he will make the decision to go home, and he will do so with pride, thanking you for letting him help. You will hear later, over the news broadcast that he is starting a charity in your name to help orphans.
Tell the Asari on Illium to leave her Krogan lover. If you don't, and you convince her to marry him instead, you will run into them on the Krogan homeworld, and she will be miserable. It is a radioactive hellhole that even Grunt can't stand, and she comments on how everyone hates her.
Convince the SI rep, on Illium, to purchase the Quarian's contract. Beware, this little quest is a trap, for those of us who were used to being more paragon than renegade!
The paragon option is to convince the SI rep to buy out the Quarian's contract, free her from indentured servitude, and then garnish back her wages. Think about that! You essentially are making the Quarian a true indentured servent, and have stripped her of the strict protections she is afforded under Illium law! The renegade option is to have SI employ her under her Illium service contract, which strictly guarantees that SI cannot take the Quarian offworld, and SI must look after the Quarians needs, which includes suits, medical, a clean room, and food. No ifs ands or buts.
I'm not saying all of the Renegade options are good.
Some are just plain mean.
But not all of the Paragon options are for the best either.
It's almost like BIOWARE impelmented a system that would make you consider whether a response should be Paragon, or Renegade, then later, down the line, decided that it would be better if all of your responses were consistently either paragon or renegade, and punish you, if they were not, by not giving you enough influence to get either option, later in the game, if you were not more one or the other.
So I play Renegon, and you know what? After doing that for a few playthroughs it is hard to see ever going back to full paragon or even paragade.
The only sacrifice, to my conscience, that I have to make, is for Zaeed's mission; as I may use that mission to give my renegade points a boost. I do have a metagame rationalization for it, but I am not always able to buy it.