
My best advice would be to practice Sniping and using the Hand Cannon. Both these weapons can be massive Equalizers, especially against the major bosses and harder enemies.
I use a Widow Anti-Material Rifle (having selected specialized training it in when offered). This weapon takes out enemies with one headshot, Scions in 3 shots.
You only really need Inferno Ammo (splash damage on organics) and Disruptor Ammo (for synthetics).
Adren Rush aids in Sniping.
Geth Shielding increases your shields, as well as being useful as a quick shield restorer.
Although I've never used Concussive shot, players who have don't approve of it.




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