I found him a nightmare the first time around. Lift will work on him, even on insanity. Damping stops him from using some of his attacks but not others, he still manages to use the sabotage beam ocasionally. Overload is good to keep pressure on his shields. But the first time around I pretty much had none of that stuff available.
He can be hard to hit but you can aim with the power wheel up. Its a bit cheap but when ever he lands you can bring up the power wheel and aim at him. As for being sabotaged pistols are the best weapon without point investment so even if you haven't put points in them it's better to use them to do some damage and prevent his shield recovering than just wait for your main gun to cool.
soteria wrote...
Is this fight really that much harder on the harder difficulties? My infiltrator sniped him down easily enough on veteran, first time ever. I just didn't think he was that hard to hit.
I haven't fought him on Veteran or lower since my first play but as I recall the fight, massively harder. He only takes a handful of hit with an SR on Insanity he takes a serious beating. Vetran and easier the Sniper Rifle is the best weapon because its damage is front loaded. The bump to health on higher difficulties makes that front loading much less useful and the higher DPS of pistols makes it king.
IIRC Glider Sarren is organic, Terminator Sarren is synthetic.