I've also thought doing a duo run with Dagny and Glorydd, but I usually enjoy the game more with NPCs than with custom chars.
Understood.
Someday Norgath and Alesia should do a multiplayer run. Or may be Glory'dd and Alesia.
I saw that Saros took one through the Trilogy, but there's no info about that run anymore, except that he played with Improved Anvil (a mod I've never tried).
Improved Anvil is very different. It's almost like another game. When I did my Improved Anvil v3 solo, the spell systems and ability systems were similar, although with significant differences. Since then the differences have grown substantially.
Improved Anvil is perhaps worth trying, but it is no reload unfriendly by principle of design. The designer severely disliked Saros's no reload runs and with new editions made significant efforts to prevent Saros from repeating his success. Additionally, IA canalizes your gameplay options: a number of party configurations just won't work.
I also find the gaming culture surrounding IA unpalatable. Closed, authoritarian, and elitist are words that come to mind. The Tzar can be unpleasant to deal with as well. I prefer open egalitarian communities, populated by people who don't take themselves too seriously. The IA world isn't for me. Note well though: I'm sure there are awesome people in the IA community, too. The norms just aren't to my liking.
Best,
A.