Right, attempt with Ascension and parts of SCS. Full log below, starting with a halfling assassin.

I grab some easy experience and a pair of boots from a gaudy hobgoblin (surreal moment as the hobgoblin is killed and drops inventory, but continues to fight for several seconds with a status of dead).
Nashkel mine is heaving with kobolds so I sneak around them. One group are blocking an exit so I am stuck. I backtrack but forget to hide after passing Joseph and get spotted. I manage to hide again but a huge group of kobolds block my path out. I retreat and try to rest. I eventually succeed but several more groups of kobolds seem to have remained despite my rest. Luckily those blocking the exit have spread out again so I find Emerson and tell him I will be back once I have recruited some muscle.
Ubuntu 11.10 & Wine.
ASCENSION. Tougher Abazigal, Demogorgon, Gromnir, Illasera, Yaga-Shura.
BG2 Fixpack. Core Fixes, GTU Light (by Wisp), BETA Core Fixes, Improved Spell Animations, Corrected Summoned Demon Behavior, Additional Script Fixes, Bard Song Fixes, Additional Alignment Fixes
Baldur's Gate Trilogy.SCS. Initialise, Faster Bears, Allow player to choose NPC proficiencies and skills, Allow Yeslick to use axes, Remove blur effect from displacer cloak, Better calls for help, More sensible choices of weapon proficiencies and kits for fighters (also fixes some errors in fighter stats), Smarter deployment, Smarter sirines and dryads, Slightly harder carrion crawlers, Smarter basilisks, Improved doppelgangers, Harder giant and phase spiders, Tougher Black Talons and Iron Throne guards, Improved deployment for parties of assassins, Dark Side-based kobold upgrade, Relocated bounty hunters, Improved Ulcaster, Improved Balduran's Isle, Improved Durlag's Tower, Improved Demon Cultists, Improved Drasus party, Improved Undercity party, Improved minor encounters, Tougher chapter-two end battle, Tougher chapter-three end battle, Tougher chapter-four end battle, Tougher chapter-five end battle, Tougher chapter-six end battle, Improved final battle.
SCSII. Initialise mod, Retrieve Dropped Items from Hell, Remove animation from the Cloak of Mirroring (leave it for other spells and effects that use the same graphic), Remove the blur graphic effect from the Displacer Cloak, Improved golems, Give fiends more staying power by increasing their hit points (this component has no effect unless Improved Fiends is installed), Fiends cast spells like normal wizards, Genies cast spells like normal wizards, Give Celestials slightly more staying power, Celestials cast spells like normal wizards, Give dragons more staying power by increasing their hit points, Standardise dragon immunities: dragons in Shadows of Amn get the same immunities to vorpal attacks (etc) as their Throne of Bhaal cousins, Dragons cast spells like normal wizards, Improved Vampires, Smarter githyanki, Only selected ToB mages get HLAs, Only selected SoA mages get HLAs, Only selected ToB priests get HLAs, Only selected SoA priests get HLAs, Smarter Illasera, Smarter Yaga-Shura, Smarter Abazigal, Smarter Gromnir, Smarter Melissan, Give Ascension versions of Irenicus and Sendai SCSII scripts and abilities, Improved Shade Lord, More resilient trolls, Increase difficulty of level-dependent monster groupings -> Significantly increased difficulty, Improved Random Encounters,Improved d'Arnise Keep ("Tactics Remix") -> Enhanced spirit trolls (as in Tactics), Slightly improved Faldorn, "Toned-down" version of the original Tactics Improved Bodhi, with SCSII scripting, Party's items are taken from them in Spellhold -> Normal mode (recommended), Improved battle with Irenicus in Spellhold, Improved Beholder hive (adapted from Quest Pack), Slightly Improved Watcher's Keep, Improved Irenicus in Hell (Tactics remix) -> Tactics-SCSII hybrid, Improved Fire Giant temple, Enhanced Sendai's Enclave, Improved Abazigal's Lair, Improved Minor Encounters.
Generalized Biffing.