1) Know your class. Sounds very Zen, but it is one of the most basic tips i could give you. The class you choose determines the weapons and powers you start with, and in turn the range at which you should stay during any battle.
2)Choose your team wisely. It's easy to fall into the habit of always taking along the same people. Though this may work on lower difficulties, it will make insanity insanely hard. The team mates you take along should depend on the defenses employed by the enemies you are about to fight. Below are some examples.
Blood Pack Mercs: Grunt is useful because he has incendiary ammo, and a shotgun. He also has heavy armor and a lot of health, not to mention the ability to regenerate pretty fast. This makes him efficient in handling regenerative Vorcha and Krogan. His shotgun, large amount of health, and unique charge ability make him one of the best team mates to counter melee enemies. The other slot can be filled by Jacob or Mordin
Blue Suns and Eclipse Mercs: Garrus and Miranda are the teammates i prefer. The both have overload, which takes care of shields. Miranda also has Warp which is useful for fighting the occassinal vanguard.
Melee Enemies: Grunt and Jacob are what i use. Grunt is very efficient as i said before. Jacob also has a shotgun and a fair amount of health, making him the next choice.
Collectors: Miranda and Grunt. They can take care of Barriers and armor collectors use. Grunt provides protection against Husks and abominations
Mechs and Geth: Tali and Legion. They have AI hacking which makes these levels almost too easy.
If you don't have some of the teammates mentioned here they can be replaced with Miranda who is extremely versatile and can take care of any enemy type.
3) If you are certain that your team mates will die in a certain battle, leave them behind. Put them in a room behind you and face the battle alone. This makes sure that you can use their powers without killing them. If you taken them along anyway, they may die and you will lose access to their powers.
4) If unsure whether you can deal with the enemy where you are now, turn around and backtrack till you reach a suitable cover position. This means that enemies will have to follow you and leave their cover behind. Most probably they will come at you in a single file making them easy to kill.
5) Some enemies ahve clear weaknesses that can be exploited to instantly kill them once their protection has been removed. Husks, Abominations and Mech are very prone to getting shredded by Concussive shots. Abominations also die instantly if Incinerated. Enemies with flamethrowers, like Geth destroyers and Blood Pack pyros can be killed with Overload or Incinerate. A well placed shot on the tanks on their backs also does the trick.





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