This is a dilemma all writers face come the end of a series of books dealing with the same characters, and one I am facing as I write the last book in my series.
Who do we kill? Some readers/gamers in this case, like everyone on the main Team. Do you roll a dice? Choose arbitraily? Look at who hasn't had the sh$% thrown at them in a long while and choose them to die?
There is no right answer. What I'm going to do is earmark a couple of folk who will either die or be hurt extremely badly, only the story as it progresses will tell me who and when exactly.
When I played ME2 the first time, I lost all the crew as I hadn't read up anything on the game, I was playing it pristine. I also saved everyone on the Suicide Mission by choosing the right folk for the job, by good luck and paying attention to their people skills.

I was delighted to save everyone. Yes, it was still a suicide mission, but if you are a good leader, know your team, choose the right person for the right job, there is no reason why you cannot bring them all through alive. Then the only casualties were the whole of the crew apart from Joker. Believe me, I felt that was a high price my Fem Shepard paid for success! (then my stupid PC got a virus and I forgot to save the saved games before reformatting the HD as the only way to thoroughly clean my system. Argh! More collateral damage!

)
Pointless deaths are just that, pointless. The aim of the game is to try and have as many survive as possible, isn't it? Therefore I have no problems when my folk do survive. I am talking about the first playthrough, not all the others where folk try to get folk killed off. That is up to them, probably another form of "beating the game" in their own way.
So I am against deaths just for the sake of them. I like my team and if I mae the right decisions, knowing them, I expect to bring as many through alive as I possibly can.
As for ME3, Bioware has said that though it will be darker, there will be a lot more fun and giggles in it too.
Taken from here
http://www.oxm.co.uk...le.php?id=19778 Casey Hudson talking to Xbox magazine June 2010
So should we be expecting something even more mature for Mass Effect 3? [Laughs] Well, we're not talking too much about Mass Effect 3 right
now, but the second story in a trilogy is where you traditionally end up
in a fairly dark place. The third story is where you try and bring some
fun and lightness back into it. One thing we tried to do with Mass
Effect 2 was as well as bringing in the more mature stuff, we also tried
to bring in a lot more humour so that we can go to these places without
making it an overbearing experience. I think we have a lot more fun
this time through characters like Joker and EDI. Mass Effect 3 is going
to be the epic conclusion... so, a lot more darkness but also a lot more
humour.