Hmm.... Well again in no particular order:
1)
Baldur's Gate 2: Shadows of Amn - Much as I like Dragon Age, it has a long ways to go before it can match this incredible RPG.
2)
Jedi Knight 2: Jedi Outcast - **** The Force Unleashed! This is the only Star Wars game where playing a Jedi felt like something straight out of the movies.
3)
Ninja Gaiden (Xbox) - One of the best action games I've ever played on any system.
4)
Batman Arkham Asylum - The first game where you truly felt like you were the goddamn Batman.

It's also the greatest comic book game ever made.
5)
Mass Effect 2 - One of the ways I judge a game by how many time I've replayed it. I've replayed ME2 more than 100 times, give or take. Does that say something?

6)
Red Dead Redemption - Not only the best Western game ever made, but also the best Open World game I've ever played. Also has one of the greatest (and saddest

) endings in videogame history.
7)
Jade Empire - A Chinese epic RPG with one of the greatest stories in a videogame, bar none.
8)
Grim Fandango - A Noir infused tale set in the Land of the Dead? Who wouldn't think that awesome? Plus, it's gotta be one of the funniest games ever made.
9)
Prince of Persia 2008 - Okay, I'll admit that
Sands of Time had better gameplay. But this one not only had one of the best female characters(Elika), but also one of the most shocking endings in a game. What is one grain of sand in a storm indeed...
10)
Assassins Creed 2 - A huge improvement over the original, and set in one of the most gorgeous periods in Human history.