My apologies, you're right. Although the difference is I normally get the grammar correct, but my typing speed tends to create the odd typo, either jumbled letters, or the letter next to the one I wanted. Unfortunately, as along time on-call tech, I have never been able to get out of analytical mode, its pretty much on 24/7.
You jumping accounts gave the impression of being a random troll. My profile pic is that of a Warhammer Troll Slayer, so I sort of leapt into the fray like any good troll slayer would.
Like Fredvdp, I am able to alt-tab out to windows pretty much at will. Unlike him though, I play in full screen mode, and my system specs arent anything special. The screen shots of the ME2 config utility showing specs in the "Read First" thread are actually of my system. Both my desktop and ME2 are running at 1600x900.
As the other have mentioned, try running both at the same resolution and colour depth.
Are you running any MP3's or other music in the background on your PC while you are playing? Or viewing any sort of web animation (ie Flash/Silverlight) that has its own audio/video properties that could be interfering?
I dont hate Windows as much as much as I hate Microsofts methodology. They seem to think that shinies should take priority over security, stability, and functionality. Windows ME and Vista (before the service packs stripped out the crud) are 2 great examples of this way of thinking.