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[padaE]

 is teammates being indoctrinated. Imagine you having to shot down you own companions... yeah there was Wrex in ME but is this case it would be more like Bastila in KoTOR, much more dramatic...
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Even better is if something like that happens with Shepard. Now, if we consider that reaper technology was used to bring him back then something beyond simple indoctrination can happen, more like "assuming direct control" stuff. It's not that far fetched, remember Overload, I don't think a human would be affected the same way by that virus or whatever as Shepard has. 
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Anyway, the main point in all this is: I hope indoctrination plays a major role in ME3. 

[b1n0ry]

I hope Tali is indoctrinated so I can leave a bullet in her face shield.

[DocGriffin]

padaE wrote...

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Anyway, the main point in all this is: I hope indoctrination plays a major role in ME3. 

I'm sure it will, what with all the Reapers flying around.

I mean I don't want to see one of my squadmates turn into an oozing blue husk just so I blow their face off, but I won't deny it would be pretty dramatic and epic.