Yes! Let me just get this first one out of the way, as it's not plot-related. I can't even recruit Isabela because of that freaking slo-motion bug. I don't have any desire to be her "rival," so I just avoid her altogether. Of course, now it's really starting to bother me that she will either show up and steal the relic, or I won't ever have access to the relic, and I'll have no choice but to kill the Arishok. It's really screwing up the story I had in mind, and you miss out on access to exp, coin, and a poison dealer if you skip her. It's getting annoying as hell dealing with that.
Okay... siblings, specifically Carver. Knowing that he has no real bearing on the majority of the game makes me want to leave him behind on missions in Act 1. Why should I be wasting friendship/rivalry opportunities on a temporary companion? At least Bethany maxes out quickly, so I can justify bringing her along for a while, but becoming friends with either of them is pointless. And no, I have no interest in maxing Carver on rivalry.
Alright then... Anders. Let's get him out of the way. I feel dirty when traveling with Anders. Having knowledge of what he's going to do and how insane he is can be troubling. Especially now that I'm playing as a warrior. Those Creation-school boosts (which they decided to deprive Merrill of ty so much Bioware >.>) can be addictive, especially Haste. So not only do I not like traveling with him, but his eventual fate makes me nervous about how viable my team will be in the end. Guess we'll just wait and see.
Leandra. I don't even like looking her in the eyes knowing about her BS fate. It's awful. That's about all I have to say about that.
The others... well, those are the ones I have any strongly negative feelings towards. But let me just point out that this happens in every game that tries to tell a story. Once you've seen it, it's difficult, if not impossible, to remain completely objective.