I'm all for the High Sparrow eventually getting his comeuppance, but I'll always root for him against Cersei. Lena Headey has been amazing this season, but her acting ability isn't enough to get me to sympathize with Cersei. She's one of the most vile players in the game, and she'd have to be be up against the Boltons or the Freys to get me to root for her.
See, I've always kinda sympathized with Cersei. Her dad was a jerk. She was so screwed up in the head from him and the death of her mom that she fell in love with her own brother, while vehemently hating her other brother. She had two nice kids but one nasty one and at one point he was King over her, making threats against her. She was basically told from the time she was little that she'll be nothing more than a princess married off to some a-hole king or another - that she is not allowed to actually rule. Though if you think about it, she would have made a far better ruler than the mad king, Robert, Joffrey, or Tommen.
It's funny how a few characters are like, "Oh Tyrion you would be the perfect ruler!" All the while I wonder if Cersei would be better than him since she has more self control. I mean, Tyrion's tendencies kinda remind me of Robert's. Both are pretty indulgent drunks. Cersei isn't really like that.
She also never struck me as a person who favored cruelty like Joffrey did. On more than one occasion she chastised him for being so irrationally cruel - telling him that it won't help him as a king. She wasn't even happy that Joffrey chose to behead Ned Stark. Remember? That upset Cersei in the moment. Countering that, she isn't a giant baby/pushover like Tommen - acting all weird and hipster-Ghandi about the out of control religious fanatics. Didn't even lift a finger to save his own (hot) wife! Nevermind his mom! ha. And she's really not like Jamie. He's fairly self centered, I would say. Cersei rarely thinks of herself, if you think about it. My god, she endured starvation and thirst so as to not de-legitimize Tommen's claim to the throne. She even walked naked through a crowd of people throwing poop at her. She wasn't about to admit to her affair with Jamie, and that wasn't to protect herself. She was already in a position of pain and suffering. She was protecting her family name. I am pretty sure Cersei would endure torture and death if it meant protecting the family name. As a ruler, she would presumably feel the same about the kingdom that should come under her own legacy, since all the citizens beneath her would become her proverbial "children." (I'm not saying she'd suffer and die for them, but there would be a certain degree of their pride connected to it all that she would fight to maintain. It's an insult to be a shitty ruler and have the people despise you. But she's never been given the chance to rule, so all the hate aimed at her was spawned by Robert and Joffrey.)
Now her daughter is dead. A girl who didn't do anything to anyone. Not once. The people (previously ruled by Robert and Joffrey) just showered Cersei's naked body in human filth. All their pent up rage was totally the fault of her dead husband and dead son. Her current son is on the throne but he's useless - and he's married to a woman who hates Cersei. (Not that Margaery is without good reason to hate Cersei. But still - that really sucks when you add it all up.) And now it looks like Cersei's only friends in the world are a crazy doctor and a giant zombie. I mean, seriously. Those are her only friends. Jamie is coming back, but is he really her friend or is he just super horny for his sister? I dunno. He's a questionable guy.
So, yeah. I always felt bad for Cersei. I'm not saying she's 100% sympathetic. She's a total b*tch most of the time. But everytime she's a b*tch, she always has a solid reason. It's never completely out of left field, irrational, or uncalled for. The woman has seen some sh*t. (no pun, regarding season finale)