I always hated that,all the characters that do a 180 on the ship, I understand the potential for reward,I also understand
that TIM can go to hell. that the potential for failure is there.You need every resource you can get,and not using the base wastes all those lives,but if Cerberus finds anything will they even be able to use it? how will they use it? it has been said that we only go to clean up their messes and we haven't seen their successes,which is exactly why it can be argued that blowing up the base was the right decision.It isn't metagaming to think Cerberus is going to royally fail,Shep has seen plenty of Cerberus failure,admitedly not total failure but the point is still valid.
And this is all semantics until ME3 comes out and one side gets to neenerneener the other,or figure out it didn't make the slightest difference.