I think this is the wrong way to frame the issue. No choice "backfires," it just puts you on another path. The Renegade way is the expedient way, the most straight-forward path. A sort of "end justifies the means." It would make since that acting in an expedient way would tend to have different sets of consequences than acting in a more morally upright manner.
That said, I think just stating whether all of these will "backfire" depends on how you look at your Shephard and what the outcome is. The Renegade path is always focused on the more narrow objective of victory at whatever costs. The Paragon path is a little more nuanced. I think in ME3 it will depend on what you want your Shephard to be concerned with. Is the objective simply saving Earth at all costs? Or is the objective to unite the galaxy against the threat? If it is the latter, then yes, I would expect making a lot of renegade decisions would have hurt you. If it is the former, then I doubt you'll have much problem.
A renegade Shephard is going to go out and grab whatever is the bare minimum necessary to stop the threat and not waste time playing nice and building alliances that are unnecessary, whereas a paragon Shephard is going to be more consumed with trying to achieve the unity necessary to not just defeat the Reapers, but to rebuild the galaxy in the aftermath of it.
This is an oversimplification of the two paths, and everyone is going to be somewhere in between them, but talking about "backfiring" depends on what your objectives are going to be and how you are going to roleplay your character in the first place. My Renegade killed the Rachni but saved the Council whereas my Paragon spared the Rachni but let the Council perish. Neither of them let the Collector base survive, but my Renegade was a hell of a lot more sympathetic to Cerberus' other goals. I even plan to do a playthrough where my Renegade is going to turn Legion in to Cerberus for research just to see what happens. I doubt many people took their Renegades that far.
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