Who won't be coming back in your ME3 - and how will this effect things?

You will need 2 squadmates to live or you will not make it back after the SM. So if you want to have everyone die you will need to make two different versions.

Besides K/A (and let's face it, as far as game play they are one and the same and thus never really die) I try to save everyone most of the time. I even make sure Wrex is not with me when I go confront Fist. I talk to Sedonis on Garrus' LM and I half expect to see some short cameo role in ME3 where he tries to find absolution through heroics on the battlefield. Rana, Shiara, the queen ... I try to save any that I can.

Expect for Maranda. I like to kill her off. I have a primary saved game that has a Cerberus free ship at the end. Only Jacob and Maranda die and Dr. Chakwas is the only surviving crewman. What do I expect to change? I won't be stabbed in the back and the game will have a random Cerberus operative do whatever it was that Maranda would have done; also, I will probably get a nasty letter from Orianna. Oh, and I'll have to get someone else to feed my fish