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[TimelordDC]

It depends on the level of configurability. Some mice allow you to

-> record macros (sequence of key-strokes and whether you want to hold them or just press-release them)

-> switch profiles on the fly (so you can go back to using RMB as RMB in other editors while using it as MMB in the level editor, for example)

-> allow you to customize the weight for minimal strain when doing lots of movement

-> adjust DPI on the fly for fine-grained movement

I use a Logitech G500 and once I configured and became used to the extra buttons, level work has progressed much faster.