OK. No offence meant, but there have been cases in the past where people have come along with teh same problem, only for it to turn out they had got it from a torrent, and without a disk we were spending a crapload of time trying to figure out a piracy issue. Frustrating as hell, as you could imagine.
Disk 1 is the disk it requires to authenticate and play the game. Heres some things to try;
1) Check the disk for fingerprints or other dirty marks. If there are any, using a soft cloth, clean it from the inside hole to the outer edge. Do not rub in circles, as that might leave lateral scratches on the surface that can cause further read errors.
2) Do you have multiple DVD drives, and if so, do you have any disk in the other drive? If so, take it out and try again.
3) Do you have Nero SmartStart, or Roxio's disk manager loaded at startup? These can cause conflicts with the disk
4) Eject the disk, then put it back in, and let the autorun kick in, and fire up the launcher. Click play from there. Does it work then?
5) Do you have Kapersky Antivirus? That causes all sorts of weird problems with ME2, and other games that use the Unreal3 engine.