I just finished my third playthrough (probably last one for a good long while -- I have other projects I need to move onto). I feel that I've gotten my money's worth already by replaying so much!
I took Javik and EDI with me this time as my final two. It seemed ridicilous to leave Javik behind when his whole purpose was to get revenge on the Reapers and he was already planning on commiting suicide afterwards to be with his loved ones again. I brought him along so he'd go out with a bang (dunno if Harbinger's beam is the last of him or not). I brought EDI because I used her a lot in this playthrough, to really understand what I was losing by choosing destroy, and partly because I had heard she was showing up on the Normandy crash in destroy for some people. I was curious if she'd show up in mine (she did not).
The one thing that irked me was the final speech Shepard gave. In ME2, the renegade speech was all about kicking the Collectors in the balls and making them pay dearly. It was a very kickass speech. The ME3 renegade speech was very impersonal in comparison and pretty much reduced my squad to reaper fodder. Something like "if you're not prepared to die, you're already dead!" I actually switched to the paragon speech this time just because it sounded better and treated the Normandy crew with a little more respect.
I still get tickled when I see the red glow in Liara's farewell. What an awesome way to show off the morality meter. Too bad I can't use the flycam in that scene -- that had serious wallpaper potential, especially if one could capture the red dots around Shepard in addition to Liara. Liara is just freaking gorgeous in that scene.


Happy I got this shot! This will be my main wallpaper until the extended scenes come out this summer.

If they add in an armor pack where Shepard can get the alliance armor that Anderson, Kaidan, James, and Major Coats can already wear, I will be slobbering all over that and firing up a 4th playthrough. I have been wishing I could match those guys!