Chris Priestly wrote...
In the meantime, let's give appreciation to Commander Shepard. Whether you loved the ME3 ending or didn't or you just have a lot of questions, he/she has given many of us some of the best adventures we have had while playing games. What was your favorite moment?
My favourite moment was when Shepard turned to Star Child and told him to shut up, then ordered the fleet to take down the Reapers, while she made a suicidal end-run to the AI core to kill Star Child, ultimately sacrificing herself, but leaving the Reapers without a leader, and in such disarray that they were, as an old human saying goes, "fish in a barrel". Even though it was sad, the epilogue scenes were very moving, and her sacrifice seemed worthwhile.
After that, my favourite moment was probably the end of ME1, when the Council chambers are covered in rubble, Anderson finds your squad mates, and they just shake their heads -- then Shepard climbs up, rising like a phoenix, all, "hey, guys, miss me?" That scene resonates with hope. For me, it remains the defining moment of the Mass Effect series; my heart swells just thinking about it.