But genetic engineering is just as much a staple of transhumanism as synthetic upgrades. Perhaps more so, as synthetic augmentation affects the individual while genetic manipulation affects the person's descendants, and thus the species as a whole, as well (thus if you would find such a thing horrifying, you understand why I find Synthesis in general horrifying)
That's actually one of the bright spots to it: Shepard and Miranda's child, or children, and descendants, if she decides to reverse her condition, which I do consider likely, will probably be the basis for a new stock of stronger, greater humans.
I find that concept very intriguing and inspiring. I do believe eugenics programs and engineering the future is the way to go. Basically, the film Gattaca, but with less sappy Ethan Hawke moral victory and more of the physical depiction of the newer, perfect humans taking over.