My list with the actors and movies they already starred in:
Jeff "Joker" Moreau – Jake Gyllenhaal (Zodiac,
Donnie Darko)
Dr. Chakwas – Helen Mirren (The Queen, The Last Station)
Comander Shepard
- Male – Gerard Butler (300, Law
Abiding Citizen) or Matt Damon (Bourne trilogy, The Departed) - Female – Julia Stiles (Bourne
trilogy, Dexter)
Kaidan Alenko – Goran Višnjić (ER, The Girl With the Dragon Tattoo)
Ashley Williams – Jessica Alba (Sin City, The Eye)
Liara T'Soni – Ellen Pompeo (Grey's Anatomy, Catch Me If You Can) or Julia
Dietze (Iron Sky)
Garrus Vakarian – Matthew Perry (Friends, 17 Again) or Robert Downey Jr.
Udnot Wrex – George Clooney? (don't know what his krogan voice would sound like
XD
Tali-Zorah – Milla Jovovich (The Fifth Element, The Fourth Kind)
Captain Anderson – Denzel Washington (The Taking of Pelham 123, The Book of Eli)
Donnel Udina – John Malkovich (Dangerous Liaisons, Red)
Saren – Hugo Weaving (Matrix trilogy, V for Vendetta)
Matriarch Benezia – wanted to put Uma Thurman, but saw somebody else wrote it,
so Lisa Kudrow (Analyze This, P.S. I Love You)
Captain "Hold the line" Kirrahe – Jesse Eisenberg (The Social
Network, Rio) or Ben Stiller (Zoolander, Meet the Parents) (but I think the
first choice is better)
Illusive Man – Charlie Sheen (made to look older)
Jack – Rooney Mara (The Girl With the Dragon Tattoo, The
Social Network)