Reorte wrote...
We're talking about more than just the forces that take part in the war. There's a vastly bigger part of the galaxy that has no knowledge of it. That also sounds a bit like pretending that leaders in war have the full support of the populace and are therefore complicit in what their forces do. I think that it could be regarded as acceptable - by them - if it's the only alternative to death by Reaper but the long-term implications make me wonder if refusal is a better choice from a completely dispassionate point of view. Life that's unable to change doesn't sound like a good thing.
Suspension of disbelief goes further in soft science fiction than hard (and I agree that it is a space opera) but it can only go so far before breaking. Where that line lies obviously varies from person to person but I like them to establish their exceptions early and then stick within plausible extrapolations of those. Space opera gets more room for initial space magic than hard sci-fi does (which usually tries to avoid any scientific exceptions and sticks at most to engineering ones).
Edit: Considering the general tone of this thread I think some of this post sounds a little confrontational. I've not thought of a good way of editing it down so hope this excuse will do instead 
In comparison with the majority of the posters I've encountered, you've been more than civil. It's enjoyable to actually have a conversation rather than seeing insults and unilateral opinions spouted back and forth.
It's difficult to have a completely dispassionate view. Ultimately if we are to take the twitter responces are true, the next cycle ultimately uses the Catalyst anyways so the point of not using the catalyst is moot - you just pass the responsbility to use it on to the next cycle. The refusal ending ultimately boils down to a matter of pride-do you die because you don't want to sacrafice your principles (and in my opinion, your pride) or do you take responsibility for the Galaxy and make a choice.
Each decission in the final bit of the game is an increasing scale of responsibility. The least bit of responsibility is refuse - you reject the notion of taking any responsibility, therefore the next cycle takes it upon themselves to use the Crucible in the eventuality that your atlernatives fail.
Destroy is the second least amount of responsibility assumed: The death of Synthetics is on your head, but it's only temporarly. New Synthetics can be made, though the old may never truely be recovered in full. Given the fear of the Reapers that was just destroied, it may be a long, long time before they be recreated. Ultimately, however, what is done after this choice is not your concern - you did your job.
Control ending assumes more responsiblity, you become the ruler/guaridan of the Galaxy with the reaper army. It's on your shoulders to rebuild and keep things peacefull between Synthetics and Organics, and you assumed the power, and inteligence, to do so. But you sacrafice yourself, and ultimately, your humanity. There is no telling if you do not eventually come to the same conclusion as the Catalyst.
Synthisis is the ultimate responsibility - but it yeilds the ultimate reward - Utopia. You do have to make the decission for the Galaxy and while some people may not wish to live in a 'perfect world/galaxy' would the cries of the dead and the suffering be worth drowning the others out? It is the ultimate 'for everyones's best interest'. Viewpoints often change the more knowledge is open to them - what happens when every single individual is granted the sum of all knowledge, but retains their individuality. The Galaxy sacrafices a lot, but gains pretty much equal parts.
Synthisis is ultimately Pandroa's Box in this regard - the consequences are beyond our understanding. But as I sit back and watch our
real life - how much conflict is born of ignorance and difference, I almost feel as if it would be a mercy to do whatever you could do to end it.
As far as the concept of suspension of disbeleif - that requires a much longer post to explain and I'm out of time. But it's interesting that people can be completely ok with Indoctrination, Biotic Fields, Mass Effect in and of itself, yet not Synthisis.