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[Sanguinus_One]

Hey,

for all of you who are interrested in a solution of the problem:

While playing the game a second time I encountered the GPF every time I wanted to leave the citadel for the last time after the Udina/Anderson cutscene.

Needless to say that I did not change anything vital on my system between the last game and the current:
Windows XP SP3, 2 GB RAM, Radeon HD 5850.

Latest video drivers or previous versions did not work.
Deleting all My Documents .ini files did not work.
Deactivating AV/Firewall Software did not work.

Problem solved by installing ME again (the EA Value Games version, then the 1.2 Patch, then DLC(s)) - despite the fact that no dynamic files (savegames, configs) were harmed in the process. Strange, but 
obviously
there had to be some damaged game data files somehow.

At least this worked for me.