Byne I don't believe Bioware can do anything. Future wise for ME. They are stuck for a new ME game that takes place after ME3 because there are mutiple endings. They would have to pick one that can have a good storyback ground, and major conflict.
Most likely Destroy, and Control. Refuse offers the next cycle to fight the Reapers, yet in the end we know they are defeated, so what is the point?
I also don't recomand Bioware making ME games before ME1. It's a bad move because we know that all the cycles in the past were harvested. To make a new character knowing that no matter what you do the future is set in stone.
Unless they make the new trilogy about the Reapers origions, then maybe, but unlikley.