If you think inventory in DA:O is a problem, don't try Titan Quest. WIthin 15 minutes of starting you'll be making a trip back to town every minute (literally) to sell loot. Then you'll acquire one piece of an elite set, then a different piece of a different elite set, and another and on and on. Then you'll pick up runes to upgrade your gear, but runes are best used in sets of three, or four, or five. You'll acquire potions by the dozens, but they only stack 10 at once. And you'll play inventory Tetris. There is no inventory Tetris in DA:O. Here is inventory Tetris:
http://vaultmedia.ig..._1150139668.jpg
In spite of the pack mules in Dungeon Siege, I spent so many hours on inventory management that I dreaded finding new gear.
Baldur's Gate was an inventory nightmare. Go to the Gnoll Fortress, kill a handful of Gnolls, back to a town to sell; probably interrupted by a random encounter both coming and going. Back to the Fortress, kill a couple more, back to town. Repeat over and over. It got so bad I made a list of loot I left behind, meaning to cheat in the gold value of the loot. When the list got to be several pages long I gave up. Cheated in bags of holding for everybody, and played happily, until I tried to find something buried in the bags.
Baldur's Gate II, same story; NWN and expansions and NWN2, cheated in multiple bags of holding.
I seem to remember in Diablo 2 reaching a limit on the amount of gold I was able to carry and store.
Don't get me wrong, I enjoyed immensely each of those games (sorry if enjoying Titan Quest is heresy around here, but forbidden pleasures can be fun), but playing inventory detracted from my enjoyment.
I did run into inventory issues once in DA:O--started Circle Tower with 80 slots, about 55 taken. Ran out of space after a couple of floors, sadly went back to an earlier save, and made sure I had about 40 empty slots before entering.
And to be honest, I have Warden's Keep (a pain to use because you may have to travel across the map to get there) and the in-camp chest mod (nice to use because camp is always right there). And I did fill up both chests. I do keep track of how much free space I have. After Landsmeet I decided to empty both chests, and found only one or two items total that were really worth keeping.
And quest items don't take up an inventory slot, so why worry about unloading them?
I'm not saying the inventory system in DA:O is perfect, but I have fewer issues with it than any other game I can remember playing in the last decade.