Mass Effect 1:
- Sovereign landing on Eden Prime
- Talking with the Rachni Queen
- Ilos
- Storming the Presidium, with Sovereign starting off in the distance and gradually coming closer as you make your way up.
- "Alliance fleet, move in. Save the Destiny Ascension."
- "Goodbye, Shepard. Thank you."
Mass Effect 2:
- The whole damn intro.
- The introduction of the Normandy SR-2.
- Meeting Garrus on Omega.
- FemShep's smirk as she proposes a friends with benefits relationship with Garrus.
- Bro fist with Jacob and really, his whole behavior regarding his loyalty quest. His romance sucked, his character was butchered in ME3, but I really liked his "only sane man" role in ME2.
- The first part of the disabled Collector ship.
- The Suicide Mission and everything about it.
-- Finally taking out the Collector ship with the Thanix Cannon.
-- At the Collector Base, after making it through the first part with the vents, there's this shot of several squad members, shoulder to shoulder, emptying their assault rifles on the Collectors to keep them from entering while the doors close. It only lasted two seconds as most, but damn it was awesome.
-- Saving the Normandy's crew, with every squad member, human or alien alike, trying their hardest to get the crew out of their pods.
-- Picking Jack to hold up the bubble. Hearing her say "commander" without a trace of sarcasm in her voice... that's character development, people.
-- Getting called by your squad, hearing that they're casually holding of the assault by the entire Collector horde.
- Liara flipping off the Shadow Broker.
- The big damn kiss afterwards.
- Arrival radio chatter: "Shepard won't go down!"
Mass Effect 3:
- Mars radio chatter: "Holy ****, it's Shepard!"
- Jack rubbing it into Rodriguez why trusting Cerberus is a bad idea.
- Tarquin Victus' sacrifice.
- Grunt's last stand.
- Mordin's sacrifice / Padok Wiks' sacrifice.
- "You've been a champion to the krogan people, a friend to Clan Urdnot and a sister to me."
- The gauntlet before the Reaper Destroyer and your squad members' reactions. James' "Holy balls!" and EDI's "This redefines insanity!" stand out for me.
- Reaper vs. Thresher Maw.
- Thane deflecting Kai-Leng's sword with his Phalanx pistol.
- The boss fight against the Reaper on Rannoch.
- Brokering peace between the quarians and the geth.
- Traynor managing to track Kai-Leng far enough to give Shepard a fighting chance again.
- Killing Kai-Leng.
- The arrival of the fleet.
- Shepard's final goodbye to Garrus.
- The Extended Cut's Synthesis ending. It's not my canon ending and I don't care if it doesn't make sense: EDI's narration and hug with Shepard's LI were beautiful.
- That squad of Asari warriors on Thessia in the Destroy ending.
- Traynor's toothbrush.
- The final boss fight against CloneShep.