Reapers
Adept: Krogan. The lack of dodge and the focus on close-quarters that comes with Barrier and Shockwave leads to his proclivity for being executed by Banshees and Brutes. Slaughters minions, but any Adept does that.
Soldier: Turian Havoc. Does not do enough damage because of the lack of grenades. Havoc Strike leads to the same problems that mean the downfall of the aforementioned Krogan Shaman. However, Cryo Blast is handy against armor and he does have better defensive stats.
Engineer: Saboteur. Lacks a strong offensive power that can be used effectively against a large group of people. Homing Grenades are strong against Banshees, but you have to find a way to drop their barriers first. Only two enemies can be hit with Sabotage, and they are both easily dealt with anyways.
Sentinel: Volus. This is the only class that I would say unequivocably sucks. He is good for nothing besides supporting teammates with Shield Boost, and you can use an Adept for that.
Infiltrator: All are good against the Reapers, but I'd say the worst is the N7 Shadow. She's very squishy without the Geth's accuracy and rate of fire bonuses.
Vanguard: Volus. He just seems very out-of-place in the Vanguard category. I use him just like the Adept: I avoid biotic charge and focus on Shield Boosting.
Geth
Adept: N7 Fury. For a character that relies on speed, the frequent staggerlocks that Geth throw out are a death sentence. Shaman actually works very well here, since Geth lack instakills.
Soldier: Geth Juggernaut. I let personal bias get in the way here: I hate this character, but I know some who swear by it. All of the other soldiers are strong.
Engineer: Vorcha. It can't deal with armor very effectively, and it can't deal with shields at all. Another wonky character.
Sentinel: Volus. All of these are going to be Volus.
Infiltrator: Drell. As much as I love Infidrells, they don't cut it against Geth because of the same problem the Fury has. Being locked in one place is a death sentence against Rockets, Railguns, shotguns, and flamethrowers. And that's assuming the bombers ignore you.
Vanguard: Drell. Same reason as the Infiltrator and Adept. He can't refill his barriers without extremely judicious play.
Cerberus
Adept: Justicar. Reave may be one of the best powers in the game, but that doesn't save this class from being very ineffective against Cerberus. Biotic Bubble is very prone to lag, and running in to deploy it often leads to death. Likewise, Pull doesn't work against armored targets, and the explosions are worthless anyways. If you've got a trooper in the air, just shoot him. It's faster than the cooldown.
Soldier: Geth Juggernaut. See above, but he is more useful due to his ability to soak up Phantom swords.
Engineer: Saboteur. His Sabotage can affect every unit but Phantoms, and they will give you Hell for choosing this class. His relative lack of dealing with shields is his undoing.
Infiltrator: Huntress. She can't deal with Shields, and all Cerberus have them besides Guardians and Assault Troopers.
Vanguard: Volus. Very awkward in general, stick with the Adept.
Collectors
Adept: Collector. He can only use his powers once every eight seconds or so, and the Collectors come much faster and harder than that allows. Also, he doesn't have Warp, and the Collectors like their high-armor units.
Soldier: Human and BF3 are equally bad. Despite Adrenaline Rush being a fantastic power, especially with a Claymore, they just can't keep up with the Collectors. Frag Grenades, Carnage, and Concussive Shot are all equally antiquated by high armor values.
Engineer: Vorcha. Armor makes this character look like an imbecile due to his lack of a flammenwerfer. Also, he's very squishy unless you stack Bloodlust with Abominations and Troopers, and those run out by wave four or five.
Infiltrator: Quarian Female. Despite her nice assets (keep it professional), she lacks a continuous means of eliminating armor. Sticky Grenades work well, but they have to be fully specced for Armor Damage, and they are finite. She does slay mooks very well though, but every Infiltrator does.
Vanguard: Cabal. It pains me to say this, but the Cabal sucks against Collectors. Her powers revolve around the use of Poison Strike to get behind bosses, but the problem is that the Collector mooks support the Praetorians and Scions very well. I often Poison Strike through a Praetorian into a couple of Possessed Captains.
Well, that's my opinion. If you disagree; fine.
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