I also started up a Vanguard on ME1. Just starting Eden Prime and I've managed to try and talk to people with space bar half a dozen time along with throwing two grenades trying to reload. Interesting side note: This was the first time I've watched the intro and not gotten chills. Makes me wonder if finishing ME3 for the first time has anything to do with it.
Haha...I do that too. I re-map ME1 so that space bar is for interacting with stuff and change grenade from R to G so I don't waste them when I reflexively "reload".
Yesterday I recreated my anti-social Shep and she looks a bit better now. After Eden Prime, she didn't talk to Chakwas, Kaidan, or Ashley. While on the Citadel gathering evidence against Saren she managed to ignore Chorban, Mr. Bhatia, Emily Wong, and Helena Blake, among others. She did recruit everyone available though and did a bit of shopping. She is now heading to the Normandy to see what Udina wants.