It mattered a lot more in ME1, especially early game.
For ME3 you can get away with a lot more combinations largely because Tech combos can be detonated by any direct damage power, and because the enemy types and compositions does not really punish certain squad compositions. Every squad member can be somewhat effective against every enemy.
ME2 was in between, although most squad members were best against one faction and not quite as good against others, with a couple exceptions.





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