My predictions (which are as predictable as trying to guess the lottery numbers by reading tarot cards)
:
- If the Architect is alive, he'll help the Inquisitor by leading an army of darspawn against the Archdemon. He may even come to die fighting Corypheus, in a sort of sacrifice scene.
- The woman made of light that helped the Inquisitor is the key or Anchor. She inhabited his body the moment they touched. She is a spirit of the Fade.
- Corypheus is not the real villain. The magisters of Tevinter are behind the Breach. But even they might be commanded by some unknown force.
- If Anders is alive, he may have vital information regarding the Breach. He may know who is the villain behind it. He may even identify the spirit that helped the Inquisitor survive and reveal its mission. If he died, then he'll show up anyway, having somehow survived being stabbed in the back.
- At least half of our companions will be dead before the game ends. Only two or three will survive and follow the Inquisitor to the final fight.
- Flemeth is immortal because she drank from the dragons's blood (and told King Calenhad to do the same). She is not a dragon, but she does have some connection to the beasts. Hence her immortality and why you can't kill her in Origins. Also, her reason for wanting to preserve the soul of the Old Gods is connected to their life. If all of them die, maybe she'll die as well.
But Flemeth already knew the Old Gods were destined to become Archdemons, so she took some precautions. She knows what Morrigan is about to do because she took the very same steps as a young woman in order to protect herself from the coming storm. Which is why Morrigan is also an OGB.
- We saw two dragons fighting in the trailer. One of them may be commanded by Flemeth - or be her, shapeshifted. If it's not her, then their deaths will result in her death as well. Morrigan may outlive her mother, after all. And regret to see Flemeth's demise.
- Alistair will render aid to the Inquisitor once he knows there's an Archdemon around. He will summon his armies (and maybe the Wardens of Ferelden) to help in the fight.
- The Qunari may become involved with the Inquisitor if a Blight threatens Par Vollen. If Sten became Arishok, he may send an army to help us. Or we may end up meeting the Qunary amy during one of our missions.
Can't think of anything else for the moment. That's about it. 