Since people are discussing whether the genphage should be cured I say no.
http://social.biowar...17881795-1.html
But a poster on an old forum also explained it beautifully.
PirateMouse said:
Well, since this thread has risen from its grave, I will reiterate my own take on this, which is very similar actually to Dean's: to wit, hell no I wouldn't cure it, and in fact I'd go to the same extreme lengths I went to in order to stop the Reapers to prevent a cure, because it's a similarly galaxy-level threat. I wouldn't even cure it if krogan culture changed, because honestly I don't care what your culture is like, 1,000 viable births per year times about 1,000 years per krogan female with each offspring living potentially around 1,000 years as well is a recipe for unqualified, unmitigated disaster the likes of which we cannot truly even properly comprehend.
At most, I would consider a reworking of the genophage, but that was never given in-game as an option. Frankly, I would wipe out every single last krogan before I'd outright cure the genophage if for some reason those were my only two options ... because that would ultimately be a choice between genocide of one species (krogans) or genocide of all non-krogans.
From there, I'll just repost my response to this topic before, which began with my feelings about the Dalatrass:
The Dalatrass is not really a character in the game; she's just a poorly disguised strawman propped up by Bioware's writers to attempt to make an irrational position more sympathetic. The angry, dismissive attitude, the way she suggests the krogan are no longer "useful" ... she could have been wearing a black top hat and twirling a pencil-thin moustache, and it wouldn't have looked out of place.
She's a symptom of what the writers pull throughout that arc, using cheap emotional tricks to manipulate and pressure the player at every turn ... and small wonder. They faced an impossible task, to present an argument that outright curing the genophage would be a good idea in spite of everything we knew (or at least could know) by then about the krogans and their horrifyingly rapid default birthrate.
Logic and reason were against them, so they resorted to the one thing they had left: emotional appeal. And don't underestimate emotional appeal! Such a powerful thing it is, so insidious and seductive. Just reading these forums, you can quickly get a sense for how easily most people are roped into terrible decisions if you tug at their emotions in the right ways. It's an excellent illustration of why the kind of power to make such enormous decisions does not belong in the hands of most people ... not so much just because power corrupts but because emotional appeal easily tempts most people into using that power in terribly short-sighted ways.
My favorite part is when people say things like, "If Wrex is in charge, it'll be fine." "I trust Wrex." "Cure if Wrex is in charge, sabotage otherwise."
In reality, Wrex being in power (yes, even with Eve there too) is a red herring.
Think about it: ONE krogan is supposed to not only change the behavior of all krogan forever but also somehow change them so much that they're able to, as a total species, self-regulate their entire population ... forever? Even though no species, including our own, has ever been able to do this as a total species? It would be an utterly ridiculous notion even if the krogan were a peaceful and enlightened species! Animals simply don't manage their reproduction in this way -- not even the sapient ones like humans.
It's moot, of course. Wrex loses power about five minutes after the war with the Reapers is won.
Or weren't you paying attention? His power base was built around control of access to fertile females. That evaporated the moment you cured the genophage, and once they no longer have a big bad enemy to fight to keep their attention, the other krogan are going to realize this. Since Wrex's ideas were hardly popular, most of them will probably abandon him overnight. Even though some may choose to remain loyal, the real force behind his unification and reformation effort is gone -- it no longer has teeth. And his relatively peaceful krogan will most likely be quickly wiped out by another more aggressive "traditional" clan.
Basically, Wrex has always been doomed. He dies on Virmire if you can't talk him down (and this is actually the best possible outcome since it makes it possible to talk Mordin down later), he dies on the Citadel if you sabotage the genophage cure, and he most likely dies later amidst the shattered remnants of his no-longer-relevant clan if you cure the genophage. Viewed from that perspective, his death can be seen as an unfortunate but inevitable consequence of his blind obsession.
I sabotaged the cure ... not because the Dalatrass was convincing but because it's simply the right thing to do. I was there to protect the galaxy, not doom it.