The more a game strives toward photo-realism, the more its less-than-realistic details become noticeable to me. Witcher 2 goes after a more "painterly" feel, hence why problems like the glow Herr Uhl mentioned don't jar me out as much.
With these screenshots, however, it's a completely different matter. The graphics seem to go after a highly "real-life" approach, with the textures, the level of detail, lighting and the color palette. However, some things such as the dragon, the stone blocks, and the facial structure/proportions of the companions are "less-than-realistic". Hence why they jump out to me in a not so good way.
Still, the game is very pretty and highly detailed, and the Discover Dragon Age trailer showed some marvelous environmental design, so all is good! 
(Forgive me if all this doesn't make any sense. I don't seem to be able to construct actual phrases today.)