I have plenty. My dad has cancer, I'm not doing well financially, I umm... yeah. Whatever. Enough of that.
I'm in a similar boat. My brother and his son both have tumors in their brain stems (so they're too risky to cut out), my dad has COPD and chronic bronchitis from smoking, my uncle has heart problems, and both heart disease and type-2 DIABEETUS run in my mom's side of the family. Considering all of my exposure to second-hand smoke, I'll probably develop some lung issues as well down the road. It's probably starting to get to me now, since it's harder to catch my breath than it used to be.
So, all in all, I'll be free of my immediate family in around 15 years, give or take. On the one hand, they're probably going to die. On the other hand, they won't be around to bother me and anymore. Joking about that doesn't bother me perhaps as much as it should. I'm not sure if it's because I'm aware of their mortality, or because I was never really close to my family to begin with (and still am not).