I have to admit I never knew about the Hayflick Limit. Generally it is applied to aging and says that a human being's cells can only divide so many times before they cease to divide. So, at the point they stop, aging is more predominant and death is near or certain. It makes the current maximum age for humans about 125 years.
My point here in this is that the Hayflick Limit states that human cells have a finite ability to divide and replicate. Synthesis certainly is shown to attach some thing to human DNA which could potentially expand cell division in some way, but this calls into question a number of things:
The human part of the cells provided by Shepard have a finite ability to replicate/divide, therefore it would be impossible for them to be shot out into every organic thing out in the galaxy; they'd have to be divided beyond the point at which a human being's cells can divide.
If the human (Shepard) DNA is enhanced beyond the Hayflick Limit then it is no longer human which again calls into question exactly what its purpose is and why it is pre-supposed and therefore could possibly be believed by Shepard to be anything good. The notion here is that a Shepard that would choose Synthesis in believing that it is good was far more likely to believe in the power of humans (organics) to determine their own future, and yet the promotion of Synthesis is completely antithetical to that idea.
The Hayflick Limit would be in direct conflict with believing that the mingling of Shepard and synthetic DNA leaves the human being intact. The very act of synthesis enhancing the ability of the Shepard cells to divide almost infinitely also leads to the certainty of at least near immortality since it is postulated that this Limit directly relates to the aging process as well as death of the body. Anything that overcomes that limit creates an extension of life. Synthesis by virtue of what happens must extend it virtually indefinitely. And that would be replete with its own set of problems as Krogan, Rachni, and everything else over-populate the galaxy. The very thing that created many of this cycle's problems (exploding populations of warring factions) would be set with no end in sight.





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