I don't know about the outrage about LI hooking up if you don't romance them.
Fenris and Isabela hooking up made sense because it's clear from both of their dialogue that they're just having a casual fling and we do get a few cutscenes of Isabela visiting Fenris' place and flirting with him, showing that she's obviously attracted to him.
Similarly, my only issue with Merrill/Carver is that that pairing only works if he's a Grey Warden, because otherwise he's kind of being a hypocritical tool for hating on magic when he's got a blatant crush on a practicising Blood Mage?
Likewise, Bethany/Sebastian I actually think is kind of cute, except for his super-pioty and him being a little too eager to murder the Mages in the pro-Templar ending, making me wonder whether he's the right sort of guy for her?
Tali and Garrus in ME3 also made some sense since there was some subtle hints dropped in a few of their conversations, as well as the fact that Garrus can be seen as a Turian version of a Paragade Shepard, so it makes complete sense that she'd be attracted to those similar qualities.
And I know most people hate it, but the rumour that Leliana and Alistair had a thing in the Darkspawn Chronicles doesn't bother me, because they're two lonely, single people fighting a war, so them getting closer and hooking up doesn't seem too far fetched? The only reason I can see them not doing so in Origins even if you don't romance either of them, is because Leliana is enamoured with and has unrequieted feelings for the Warden.
So, yeah, I don't see why Josie/Cullen or Cullen/Cass or even Cullen/Leliana would be such a terrible pairing?