I'd love a very non-stereotypical gay dude character, especially as an LI, and especially one that is heroic. It is something rarely seen in portrayal within our media. I often say that my dream for the gaming industry is to get to the point where we can have a non-stereotypical out gay action hero protagonist starring in his own game (with a boyfriend or husband love interest). Someday soon, I'll keep hoping. In the meantime, the next closest thing is in games like this where our non-heterosexual representation comes in the form of companions and secondary cast. Cortez was lovely in this regard, but I do hope for something meatier in content and a full-fledged combat companion.
The Depraved Bisexual trope is too often used as well, especially how often Depraved Bisexuals are coupled with morally bankrupt or sadistic assassin or effete villain traits, and it's a sore spot with me in frequently it gets pulled out for use within the media.
He's not the main protagonist and it's not a game, but the Pied Piper from the Flash comics is my absolute favourite comic character. And his boyfriend is the criminal investigation director, so it's not like he's a background character you never see, either. 
And then there's Teddy and Billy from the Young Avengers!
(That's not to say comics don't botch things up, mind-- they botch things up all the damn time, sadly, thanks to the constant change in writers. Still, they super-heroes? So there's that.)
*comic feels*
Edit: And just remembered there's also Northstar who got married to his boyfriend! (That's a REALLY good issue, actually.)