The debates about whether or not the romances in Dragon Age 2 represented bisexuality (in the two cases where explicit interest in both genders was declared and acted upon by the characters regardless of Hawke) have been on-and-off for years. That such a debate could even exist, and terms like playersexual or Hawkesexual or even Schrodinger's Sexuality needed to be coined in order to convey the completely viable other ways to interpret said romances, is evidence that DA2's approach was, in those cases, not "one set sexuality." That players could opt to interpret everyone as bisexual, or straight in some playthroughs and gay in others, and did opt to do so frequently, is further evidence of this. A player who wanted to imagine that Anders was gay would not have been contradicted by any of the content in a given playthrough of Dragon Age 2, nor would a player who wanted to imagine that Merrill was straight. That the opposite is equally true in both instances is, again, further evidence of this. The only way through which those characters could be said to be bisexual - and thus represent bisexual characters - is through meta-knowledge. For some this is enough, for others it is not.
What does this mean? It means Cameron's statement must be understood in that context. He is speaking to an audience, us, who he must assume is using DA2 as a frame of reference. How Inquisition will do romances is not something that has been announced, so deriving assumptions from that which we have no knowledge will invariably lead down whatever paths our instincts guide us. If we want to expect the worst from Inquisition, there's nothing out there yet to contradict us. If we want to get worked up, that's a great way to do it. It just doesn't happen to be an effective method of drawing accurate conclusions.
On the other hand, when put up against Dragon Age 2's approach, we can derive some definite meaning from the statement. If Dragon Age 2's position was one of inherent and intentional ambiguity to allow for a variety of interpretations, we can safely assume that what Cameron Lee meant to convey with his statement is only that there will be no ambiguity in Inquisition. As to whether or not that means everyone will be explicitly bisexual - thus retaining the same accessibility to romance content (I hesitate to use "inclusivity" here, for reasons I'll explain in the next paragraph), or some will be gay, others lesbian, others bi, others straight, and others pan or ace, is not something the statement can convey without more information. Nor does it convey the implication, as some have interpreted, that bisexuality is not a set orientation. It merely implies that characters will have the sexual orientation they have regardless of what gender your protagonist happens to be. Again, in direct contrast to Dragon Age 2.
Given that the many debates over Dragon Age 2's approach can be summarized as: The trade-offs of accessibility ("I can romance whoever I want with whoever I want") and representation (Where some characters can be interpreted as straight or gay depending on which gender you picked after pressing Start, it has been argued neither gays nor straights - nor indeed bisexuals - can be faithfully represented by that character within any given playthrough) in achieving the goal of providing as many players as possible with adequate options, Cameron's statement can be interpreted as evidence of BioWare having essentially agreed with the premise argued by those who say DA2's approach was not entirely representative, and that is therefore what I believe Cameron means by Inqusition's take being more "realistic." Realistically, my sexual preference is not determined by gender of the next person to walk into the room, it existed before that person ever opened the door. That I may be into women, or men, or both, is set.
I can understand any changes along issues such as these to be controversial, and have proponents and detractors. But a careful unpacking of the statement in the context of Dragon Age 2 at least provides a framework for discussion that is grounded in something other than bad feelings. Likewise, this is not merely a gameplay or replayability issue, for reasons that ought to be clear from the content of this post as well as many others.
Disclaimer: I did not carefully read through every post in this thread, only skimmed to get a sense of the discussion here (in addition to elsewhere) and made a general statement. If this has all been covered, feel free to move along.