Yeah, you have to uninstall the device drivers and let windows install basic mouse drivers and then it will work. In vista 64-bit, click Start, Control Panel, View Hardware and devices, click the + next to Mice and other pointing devices, Right click on HID-compliant mouse and select uninstall. Your mouse should stop working then, unplug it and plug it back in and Windows will automatically install basic drivers which work fine with the game but all the extra mouse features will be disabled... oh well. At least you can zoom