@Xamufam- Rana Thanoptis was indoctrinated on Virmire. What makes you think otherwise? She was indoctrinated completely, but allowed to be fully autonomous until the reaper war began. Then, the reapers used her. She was essentially a sleeper agent of sorts. It didn't take her three years to be indoctrinated.
If she was fully indoctrinated from the beginning she would not have helped, The reapers can use the victims body to amplify it's signal with the use of quantum entanglement. Rana explains in me1 that when you are getting indoctrinated you see hallucinations & hear whispers she did in me3 not in me1. she also explains that the person before her was indoctrinated.
She would not have been sane after years of indoctrination, rapid indoctrination would have been worse just look at the salarian on wirmire in me1





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