Tough choice. I honestly think a population explosion would be a disaster for the Krogan once the brief euphoria of the cure wore off. Sort of like I expect the Quarians will quickly find living on Rannoch just as strenuous as fleet life, at least in the early years. As the Krogan population grows, they'll rediscover that they're living in an irradiated desert wasteland which can't feed them and need to emigrate again. I generally go with the cure, but even with both Wrex and Eve I'd think it appropriate to partition some territory off for them and quarantine them to those systems, keeping them demilitarized for however many centuries it takes to find a new equilibrium before they reintroduce themselves to the galaxy.
The ideal solution would be a "middle-ground" cure which took stillbirths out of the equation entirely but left their birth rate exactly where it is.
I can agree with you there. When I first played I cured on the fact Wrex was my friend. But after thinking about it especially after my renegade told him on the citadel "not all krogan are like you wrex" I realized they are a tough species to trust. They have not worked out aggression and there is no guarantee that Wrex will survive the last fight or any for that matter. What happens when a young krogan takes his place. A back up plan needs to be ready to go if need be. I do think they deserve a chance but it will be the last one they get.
I only Cure the Krogan when three criteria are met. Wrex must be in charge, Bakara (Eve) must survive the creation of the cure, and the Rachni Queen from ME1 must have survived to ME3. If any one of those three are not true for a particular playthrough, I sabotage the cure. Why? Wrex and Bakara know the Krogan as a race cannot breed without constraints as that is what lead to the Krogan expansion and ultimately the creation of the Genophage. They will try to shape the future of the Krogan on a more stable path. Wreav is a war monger and cannot be trust with an unbound Krogan race. Without Bakara, the very idea that Wrex could control the other clans, without the Genophage and possible extinction hanging over their heads, is a joke. And should all else fail, the Rachni can always be brought to bare against the Krogan. With their aid, the other race could beat down another Krogan rebellion.
Besides, as I said in an earlier post, I can't believe for a second that the Salarians didn't start working on Genophage v3.0 the second they found the cured females. While I do agree the Krogan deserve a second chance, I am not blindly optimistic enough to think that a plan should not be in place should the worst come to pass. And they are demilitarized, so it would take a great deal of time to amass the resources for another rebellion.
I do agree that the Genophage was a horrible thing, but it was in response to the Krogan trying to kill everyone else in the galaxy. They refused to control their own populations. Had they simply placed limits on the number of kids a family could have at any one time, the whole affair could have been avoided. Instead, they invaded territory of other races, effectively stole planets for resources, and attacked anyone who stood in their way. They dropped asteroids on colonies and mercilessly slaughtered the populations of entire planets. All they had to do was control their birth rates and they just wouldn't do it. The Genophage was a horrible punishment, but it is one they earned.