It's going to be a reboot:
Game opens with TIM, Miranda, Wilson and a few others standing around shep's hospital bed on the Lazarus station. TIM is watching the monitors intently, silent as they flatline.
Wilson: I'm sorry, Commander Shepard is dead.
Miranda: His brain activity was off the charts these past few months. I don't understand it.
TIM *pulls out a datapad, begins entering names for firing squad detail* : It's alright, Wilson. I'm sure you did the best you could.... okay, what's plan B?
Wilson *knows that tone of voice, is eager to please* : W-well... Kai Leng is responding well to the implant treatments.
Miranda *scoffs*
TIM : Be serious, Wilson... or I'll have to shoot you.
Wilson *pales*: Y-yes sir.*
TIM: Relax Wilson, I'm kidding.
Wilson *sighs in relief*
TIM *puts Wilson's name at top of list* Miranda, where's our young miss Brooks?
Miranda: Who?
Maya Brooks *steps forward* : It's Miss Lilium, sir. Hope Lilium?
TIM *looks at Miranda questioningly*
Miranda *nods*
TIM: Okay then. Miss...uh... Lilium. How's the clone coming along?
Brooks: Fine, sir. Everything looks good.
TIM: And the control chip?
Brooks *checks pocket* : Implanted and running smoothly.
TIM: Super. You're in charge of this one, miss Lilium.
Brooks: Yes, sir.
TIM: Miri, want to take my new ship for a spin? Lilium -- I mean, Ilium is nice this time of year.
Miranda: Let's go.
TIM: Wilson, turn out the lights when you leave.
Wilson *mutters* : Kai Leng was a good plan.