I think animation would be a great way to prevent genre fatigue. I mean I love scifi, I don't get bored of this stuff no matter how many shows are on. But there are quite a few series out there now, more on the way, & I know people could get bored with them. Which is bad for me because I want moar. Animation could give something of a break, keep people interested in these shows longer.
Bioware IP's might be fun to explore, I love the concept art and game design so they already have a good resource to draw from. Mass Effect would be fun. There's allot to take from the games in a show. An animation would be perfect in that it can hit the universe in a way that games are limited. We know there's the Terminus species, and probably lots of weird aliens out there, intelligent or otherwise, animation could bring all that variety out & fill in some gaps.
I'd like to see more adult animation. With fantasy and scifi, maybe something picking up great stories that haven't had any major presence in film if at all.... Like Dragonriders of Pern, Dune, anything by Clarke, Haldeman, and other great scifi minds, or other game adaptions like Metro, Metroid, Cave Story, etc!