Naturally, as ME3 was the end game... you can finally cut loose in changing major things if that's what you want.
I personally do want a reboot. A sequel would be more choice-devaluing than ME3 could ever have been, and the Reapers will never be topped anyway.
Or they can simply come clean about the Indoctrination Theory being true, case in which your choice is a lie either way.
One possibility is that Bioware is porting the original trilogy to next-gen consoles. And that the next ME game will incorporate some major choices while converging others.
I use to be all for starting fresh but the original trilogy presents a giant space elephant in the room. Ignoring every life changing choice would simply not be a great idea.
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