I've only ever played ME once, although I've completed it several times. I just fell in love with my first Shepard and can't imagion playing the game any other way.
This is my situation. Friends and boyfriend have encouraged me to attempt a renegade playthrough with a Garrus romance and I'm like...it would feel wrong. After three games of investment in her, I can't really let go. Hell, I still have screens of my Shepard and Liara on almost all of my devices as wallpaper, and it has been a couple of years. The big version of my avatar has joined the wallpaper rotation on this laptop, and the Hierophant card joins Liara on my tablet.
If you have fun writing it, it was quite fun to read.
Hah, I can totally feel you guys on sticking to a single Shepard, though actually ME for me is an interesting question: I have a canon for both a maleShep and femShep for starters, but I do keep replaying those over and over and over. The only thing I've really changed much is the class; my femShep went from Infiltrator to a Vanguard canon over the dozens of times I've played through her. Still, it's getting kind of confusing in my game folder with so many saves under the same character name...
I actually ended up really resenting my first maleShep, who was also my first PT; I liked the romance I chose (I stuck with that) but overall Paragon didn't do it for me. I liked how I finished him off, but I didn't really replay him at all. My second maleShep was much better and I kept him around. My first femShep, on the other hand, was just awesome from day 1 so I ended up playing her the most. Dozens... and dozens of times.
I do generally try to be expansive, though, I want to try out different romances and options, so I always have a "consolation canon replay" running parallel to my variation replays and that way I don't feel so terrible about making completely different choices.
It's still tough, though, I get invested in the variations and that makes me care about their choices which makes me start leaning towards my canon choices. SIGH. Still, with DAI especially I'm soooo glad that I didn't just stick to my canon - I really enjoyed playing things out differently from the start what with the mage/templar routes and the variations on Halamshiral... all good stuff. Actually, DAI has been the easiest to replay variations for me all things considered.