I was listening to DanaDuchy's banter compilation and came across this line of Cole's, talking about the Bastion of the Pure:
Cole: It's singing. A they that's an it that's asleep...but still making music.
And I was also reading through all the spoilered lore posts, particularly Habits Honeypot's on how compulsion is a huge theme in the Dragon Age universe. And I started thinking...does Cole's description of the lyrium song sound horribly similar to Reaper indoctrination to anyone else?
His words pretty much describe the derelict Reaper in ME2.
I'm not saying it's a one-to-one comparison between indoctrination and the lyrium song, but they do seem to have similar story purposes of compelling an irreversible change in thinking and behavior. Red lyrium is blighted, and its "song" inevitably drives people insane. The Sha-Brytol are constantly exposed to blue lyrium, and they don't die, but they also seem a lot more like Reaper husks than people. Even in the short term, normal lyrium can be dangerous: lyrium-addling in dwarves, insanity and death in mages.
So...maybe whatever broke the world wasn't the loss of lyrium, but the use of it? What if it's really not meant to be used by mortals, and it also has cumulative effects over generations? It may have stripped the dwarves of their magic, the elves of their immortality. It might even subtly alter the behavior of people like mages and templars who are frequently exposed to it, in ways beyond the usual dangers.
Also, not sure if that made sense at all