There's no real evidence to say anything for certain. But if you're a female character and you're in a romance with Alistair and plan to marry him to her, you can find out Cailan had mistresses on the side. Many in fact, and Anora always knew. No bastards have ever popped up so it's likely Cailan was shooting blanks. IIRC, David Gaider said on his tumblr that the Theirin family haven't been the most noteworthy when it comes to having children, so that speaks of some problems right off the bat.
It's also possible that Anora and Cailan just never had sex, though given the intimacy of their relationship whether you accept that or not is wholly up to you.
And it's possible that yes, Anora is barren. Or that she and he were both incapable of having children.
Still, that doesn't mean anything when it comes to ruling. Some of the most famous people who ruled empires or kingdoms adopted children and groomed them for taking up their mantle. Nothing stopping Anora from taking a child a mother might not want, raising it as her own, and telling everyone he or she is her child.





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