I STILL remember that line (well to some degree, not word-for-word accuracy) from Shepard in ME3 to this day (even though I only completed ME3 one time, pre-Extended Cut, like three weeks or so after the game was released). It happens just after the fight between Kai Leng and Thane. It's shortly after Thena gets IMPALED by Kai Leng, and as Thane crumbles against a wall you get that oh-so-obvious Shepard showing up next to him (in a hurry, now that the scene is over, of course) and actually asking Thane if he's alright. I mean ... !!!!!!!!!!
It goes something like: "[insert just a bit of distress in the voice] Thane! [remove all emotions in the voice] Are you ok?". Not to mention that the actual voice tone is completely off, very monotone and without emotion. It's like Mark or Jennifer were just told to come up with a line without telling them the context.
I mean really, Shepard, REALLY? Errrrrrr... ok what about not standing there in the first place during the fight and hel- ... never mind, scripted scene. Well let me answer that one in Thane's name, Shepard. What about a big NO? He just got impaled, he was already a dying man to start with, and you're now asking him how's it going? I'm preeeeeeeeetty sure that getting impaled doesn't exactly mean that you're "ok" nor that you'd be ready to run a marathon because it'd obviously just be a flesh wound.