My only worry would be that our decisions don't have impact and every choice is either too blatantly "paragon" or "renegade." BioWare could learn a lot from The Witcher 2 in crafting choices that are neither right or wrong, but merely have consequences that you have to decide whether you can live with. I want true moral dilemmas.
I want the scenario mentioned in KotOR 1 where Revan had to decide whether to save a city full of millions of civilians, or use the city as bait, leading it to destruction, in order to heavily cripple the Mandalorian offensive in hopes of ending the war sooner. There shouldn't be a clear and obvious happy ending. There needs to be sacrifice. We need to be able to not only make friends, but definitely make enemies based off of our choices.
Many continue the criticize the ending of ME3, but I thought it was absolutely brilliant in regardless of the choice you make, something had to be sacrificed. BioWare needs to push us to the physical and emotional limits that one having such power would have to deal with. Lives are in the balance and you will decide who dies and who lives. Millions are at risk. How will you rule?