"No! No, it's not!"
"Oh."
Give it a shot. Depict your favorite Mass Effect scenes (or how they should have gone) using images and animated GIFs from other games/shows/movies etc.
Okay, I'll give it a shot... please don't hate me, Liara fans. I'm one too, honest!

Guest_Jesus Christ_*
Eclipse Merc: I've got nothing more to say to you. If you sho-AAAHHGGG!!
Shepard: How about goodbye?

Bring on the Firefly GIFs!

*Shepard upon seeing the bar in the Lounge*

Guest_Jesus Christ_*
Shepard to Elnora on Samara's recruitment mission.
Shepard: You chose your side Elnora, and you lost.
Elnora: Screw that, B*tch!

Shepard to Elnora on Samara's recruitment mission.
Shepard: You chose your side Elnora, and you lost.
Elnora: Screw that, B*tch!
Asari do kinda look like Justin Beiber.
Mmmm, whatcha say
Mmmm, whatcha say
Oh, that you only meant well? Well, of course you did
Mmmm, whatcha saaay
Oh, that it's all for the best? Of course it is...
(Yeah, I know it's a seven-year-old gag. You know you were thinking of it.)
I still find it funny when then clip is played over people shooting each other.

R-r-r-r-rudimentary creature of (blood and) blood and flesh. You t-t-touch my mind, (fumbling) fumbling in ignorance, in-incapable of understanding (understandinnnng).
Guest_Jesus Christ_*
Mmmm, whatcha say
Oh, that you only meant well? Well, of course you did
Mmmm, whatcha saaay
Oh, that it's all for the best? Of course it is...
(Yeah, I know it's a seven-year-old gag. You know you were thinking of it.)
Admittedly no, but I just saw the SNL clip, and I have a good laugh.
Shepard: Dr Cole? Got a moment?
Homewrecker: Of course.
Shepard: What's your relationship with Jacob? You know that we were together, right?
Homewrecker: Yes. I'm sorry.
Shepard: How did you meet?
Homewrecker: We met in Mumbai through an old colleague. I won't lie. I went after him. But... he still loves you.
Shepard: Why would you tell me that?
Homewrecker: Because I'm also going to tell you this: the best place for Jacob now is with me. I hope that you can see that.
Shepard: ...

Guest_Jesus Christ_*
Khalisa Al-Jilani: Sources claim that you were at the heart of the Presidium during the battle of the Citadel, it's fair to say the course of the battle hinged on your word, if true you told Admiral Hackett to assist the Destiny Asscencion, costing hundreds of hum--
*RENEGADE INTERRUPT*
Shepard:I've had enough of your disingenuous assertions!

Fry, you son of a b*tch!

This AMAZIN.